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Publications generated within the SPP 1384

Listed below are publications, which result from projects supported by the SPP 1384



Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1.
Hellmuth S, Rata S, Brown A, Heidmann S, Novak B & Stemmann O.
Mol Cell. 2015 May 7;58(3):495-506. doi: 10.1016/j.molcel.2015.03.025. Epub 2015 Apr 23.

Plant genome editing by novel tools: TALEN and other sequence specific nucleases.
Sprink T, Metje J, Hartung F.
Curr Opin Biotechnol. 2015 Apr;32:47-53. doi: 10.1016/j.copbio.2014.11.010. Epub 2014 Nov 25.

Positive and negative regulation of vertebrate separase by Cdk1-cyclin B1 may explain why securin is dispensable.
Hellmuth S, Pöhlmann C, Brown A, Böttger F, Sprinzl M & Stemmann O.
J Biol Chem. 2015 Mar 20;290(12):8002-10. doi: 10.1074/jbc.M114.615310. Epub 2015 Feb 6.

Protein SYCP2 is an ancient component of the metazoan synaptonemal complex.
Fraune J, Alsheimer M, Redolfi J, Brochier-Armanet C, Benavente R.
Cytogenet. Genome Res. 2014;144(4):299-305. doi: 10.1159/000381080. Epub 2015 Mar 28.

Elucidation of synaptonemal complex organization by super-resolution imaging with isotropic resolution.
Schücker K, Holm T, Franke C, Sauer M, Benavente R.
Proc Natl Acad Sci U S A 2015 Feb 17;112(7):2029-33. doi: 10.1073/pnas.1414814112. Epub 2015 Feb 2.

CDK2 regulates nuclear envelope protein dynamics and telomere attachment in mouse meiotic prophase.
Viera A, Alsheimer M, Gómez R, Berenguer I, Ortega S, Symonds CE, Santamaria D, Benavente R, Suja JA.
J Cell Sci. 2015 Jan 1;128(1):88-99. doi: 10.1242/jcs.154922. Epub 2014 Nov 6.


Alternative meiotic chromatid segregation in the holocentric plant Luzula elegans.
Heckmann S, Jankowska M, Schubert V, Kumke K, Ma W, Houben A.
Nat Commun. 2014 Oct 8;5:4979. doi: 10.1038/ncomms5979.

The splicing fate of plant SPO11 genes.
Sprink T, Hartung F.
Front Plant Sci 2014 May 21;5:214. doi: 10.3389/fpls.2014.00214. eCollection 2014.

PP2A delays APC/C-dependent degradation of separase-associated but not free securin.
Hellmuth S, Böttger F, Pan C, Mann M & Stemmann O.
EMBO J. 2014 May 16;33(10):1134-47. doi: 10.1002/embj.201488098. Epub 2014 Apr 29.

The synaptonemal complex of basal metazoan hydra: more similarities to vertebrate than invertebrate meiosis model organisms.
Fraune J, Wieser M, Benavente R.
J Genet Genomics. 2014 Mar 20;41(3):107-15. doi: 10.1016/j.jgg.2014.01.009. Epub 2014 Feb 20.

Analysis of meiosis in SUN1 deficient mice reveals a distinct role of SUN2 in mammalian meiotic LINC complex formation and function.
Link J, Leubner M, Schmitt J, Göb E, Benavente R, Jeang KT, Xu R, Alsheimer M.
PLoS Genet. 2014 Feb 27;10(2):e1004099. doi: 10.1371/journal.pgen.1004099. eCollection 2014.


Sgol2 provides a regulatory platform that coordinates essential cell cycle processes during meiosis I in oocytes.
Rattani A, Wolna M, Ploquin M, Helmhart W, Morrone S, Mayer B, Godwin J, Xu W, Stemmann O, Pendas A, & Nasmyth K. 
Elife 2013 Nov 5;2:e01133. doi: 10.7554/eLife.01133


Dynamic localization of SMC5/6 complex proteins during mammalian meiosis and mitosis suggests functions in distinct chromosome processes.
Gómez R, Jordan PW, Viera A, Alsheimer M, Fukuda T, Jessberger R, Llano E, Pendás AM, Handel MA, Suja JA.
J Cell Sci. 2013 Sep 15;126(Pt 18):4239-52. doi: 10.1242/jcs.130195. Epub 2013 Jul 10.

MEIOB exhibits single-stranded DNA-Binding and exonuclease activities and is essential for meiotic recombination.
Luo M, Yang F, Leu NA, Landaiche J, Handel MA, Benavente R, La Salle S, Wang PJ.
Nat Commun. 2013;4:2788. doi: 10.1038/ncomms3788.

Quantitative analysis of chromosome condensation in fission yeast.
Petrova B, Dehler S, Kruitwagen T, Hériché JK, Miura K, Haering CH.
Mol Cell Biol
. 2013 Mar;33(5):984-98. doi: 10.1128/MCB.01400-12. Epub 2012 Dec 21.

The meiotic nuclear lamina regulates chromosome dynamics and promotes efficient homologous recombination in the mouse.

Link J, Jahn D, Schmitt J, Göb E, Baar J, Ortega S, Benavente R, Alsheimer M.
PLoS Genet 9(1): e1003261. doi:10.1371/journal.pgen.1003261 Epub 2013.


Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans.
Fraune J, Alsheimer M, Volff JN, Busch K, Fraune S, Bosch TC, Benavente R.
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16588-93. doi: 10.1073/pnas.1206875109. Epub 2012 Sep 24.

Cyclin A2 is required for sister chromatid segregation, but not separase control, in mouse oocyte meiosis.
Touati SA, Cladière D, Lister LM, Leontiou I, Chambon JP, Rattani A, Böttger F, Stemmann O, Nasmyth K, Herbert M, Wassmann K.
Cell Rep. 2012 Nov 29; 2(5): 1077-87. Epub 2012 Nov 1.

A truncated lamin A in the Lmna -/- mouse line: implications for the understanding of laminopathies.
Jahn D, Schramm S, Schnölzer M, Heilmann CJ, de Koster CG, Schütz W, Benavente R, Alsheimer M.
Nucleus. 2012 Sep-Oct; 3(5): 463-74. Epub 2012 Aug 16.

The mammalian synaptonemal complex: protein components, assembly and role in meiotic recombination.
Fraune J, Schramm S, Alsheimer M, Benavente R.
Exp Cell Res. 2012 Jul 15; 318(12): 1340-6. Epub 2012 Feb 28. Review.

The transition from meiotic to mitotic spindle assembly is gradual during early mammalian development.
Courtois A, Schuh M, Ellenberg J, Hiiragi T.
J Cell Biol. 2012 Aug 6; 198(3): 357-70. Epub 2012 Jul 30.

Cohesin in determining chromosome architecture.
Haering CH, Jessberger R.
Exp Cell Res. 2012 Jul 15; 318(12): 1386-93. Epub 2012 Mar 24. Review.

Age-related aneuplodidy through cohesion exhaustion.
Jessberger R.
EMBO Rep. 2012 Jun 1; 13(6): 539-46. Review.

Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms.
Wojtasz L, Cloutier JM, Baumann M, Daniel K, Varga J, Fu J, Anastassiadis K, Stewart AF, Reményi A, Turner JM, Tóth A.
Genes Dev. 2012 May 1; 26(9): 958-73.

The Fanconi anemia ortholog FANCM ensures ordered homologous recombination in both somatic and meiotic cells in Arabidopsis.
Knoll A, Higgins JD, Seeliger K, Reha SJ, Dangel NJ, Bauknecht M, Schröpfer S, Franklin FC, Puchta H.
Plant Cell. 2012 Apr; 24(4): 1448-64. Epub 2012 Apr. 30.


Meiosis in mice without a synaptonemal complex.
Kouznetsova A, Benavente R, Pastink A, Höög C.
PLoS One. 2011; 6(12): e28255 Epub 2011 Dec.2.

Modulated microtubule dynamics enable Hklp2/Kif15 to assemble bipolar spindles.
Florian S, Mayer TU.
Cell Cycle. 2011 Oct 15; 10(20): 3533-44. Epub 2011 Oct 15.

BRCA2 is a mediator of RAD51- and DMC1-facilitated homologous recombination in Arabidopsis thaliana.
Seeliger K, Dukowic-Schulze S, Wurz-Wildersinn R, Pacher M, Puchta H.
New Phytol. 2012 Jan; 193(2): 364-75. Epub 2011 Nov 11.

CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication.
Franz A, Orth M, Pirson PA, Sonneville R, Gartner A, Blow JJ, Stemmann O, Hoppe T.
Mol Cell. 2011 Oct 7; 44(1):3-4.

SPOC1 (PHF13) is required for spermatogonial stem cell differentiation and sustained spermatogenesis.
Bördlein A*, Scherthan H*, Nelkenbrecher C, Molter T, Bösl MR, Dippold C, Birke K, Kinkley S, Staege H, Will H, Winterpacht A.
J Cell Sci. 2011 Sep 15;124(Pt 18):3137-48.
*equal contribution.

Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes.
Kitajima TS, Ohsugi M, Ellenberg J.
Cell. 2011 Aug 19; 146(4):568-81. Erratum in: Cell. 2011 Sep 16; 146(6): 1042.

Expression of individual mammalian Sun1 isoforms depends on the cell type.
Göb E, Meyer-Natus E, Benavente R, Alsheimer M.
Commun Integr Biol. 2011 Jul; 4(4): 440-2. Epub 2011 Jul 1.

Live cell imaging of meiotic chromosome dynamics in yeast.
Scherthan H, Adelfalk C.
Methods Mol Biol. 2011;745:537-48.

Nuclear lamins in mammalian spermatogenesis. In S. Rousseaux and S. Khochbin (eds.)
Epigenetics and Human Reproduction.
Alsheimer M, Jahn D, Schramm S and Benavente R. (2011).
Springer-Verlag Berlin Heidelberg, Germany.

A novel mouse synaptonemal complex protein is essential for loading of central element proteins, recombination, and fertility.
Schramm S, Fraune J, Naumann R, Hernandez-Hernandez A, Höög C, Cooke HJ, Alsheimer M and Benavente R. (2011)
PLoS Genet 7(5): e1002088.

Cleavage of cohesin rings coordinates the separation of centrioles and chromatids.
Schöckel L, Möckel M, Mayer B, Boos D, Stemmann O.
Nat Cell Biol. 2011 Jul 10; 13(8):966-72.

Shugoshin is a Mad1/Cdc20-like interactor of Mad2.
Orth M, Mayer B, Rehm K, Rothweiler U, Heidmann D, Holak TA, Stemmann O.
EMBO J. 2011 Jun 10. doi: 10.1038/emboj.2011.187 (Epub ahead of print)

Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1.
Hörmanseder E, Tischer T, Heubes S, Stemmann O, Mayer TU.
EMBO Rep. 2011 May 1;12(5):436-43.

RAP1-independent telomere attachment and bouquet formation in mammalian meiosis.
Scherthan H, Sfeir A, de Lange T.
Chromosoma. 2011 Apr; 120(2) 151-157.

Non-proteolytic ubiquitylation counteracts the APC/C-inhibitory function of XErp1.
Hörmanseder E, Tischer T, Heubes S, Stemmann O, Mayer TU.
EMBO rep. 2011 May; 12(5): 436-43. Epub 2011 Mar 11.



FISH as a tool to investigate chromosome behavior in budding yeast.
Scherthan H, Loidl J.
Methods Mol Biol. 2010;659:363-77.

Synaptonemal complex protein SYCP3 exists in two isoforms showing different conservation in mammalian evolution.
Alsheimer M., Baier A., Schramm S., Schütz W. and Benavente R. (2010).
Cytogenet. Genome Res. 128: 162-168.

Oocyte cohesin expression restricted to predictyate stages provides full fertility and prevents aneuploidy.
Revenkova E, Herrmann K, Adelfalk C, Jessberger R.
Curr Biol. 2010 Sep 14;20(17):1529-33.

Age-related meiotic segregation errors in Mammalian oocytes are preceded by depletion of cohesin and sgo2.
Lister LM, Kouznetsova A, Hyslop LA, Kalleas D, Pace SL, Barel JC, Nathan A, Floros V, Adelfalk C, Watanabe Y, Jessberger R, Kirkwood TB, Höög C, Herbert M.Curr Biol. 2010 Sep 14;20(17):1511-21.

Dynamic properties of meiosis-specific lamin C2 and its impact on nuclear envelope integrity.
Jahn D, Schramm S, Benavente R, Alsheimer M.
Nucleus. 2010 May/June; 1(3): 273-283.

The elegans of spindle assembly.
Müller-Reichert T, Greenan G, O'Toole E, Srayko M.
Cell Mol Life Sci. 2010 Jul;67(13):2195-213. Epub 2010 Mar 26. Review.

A novel mammalian HORMA domain-containing protein, HORMAD1, preferentially associates with unsynapsed meiotic chromosomes.
Fukuda T, Daniel K, Wojtasz L, Toth A, Höög C.
Exp Cell Res. 2010 Jan 15;316(2):158-71.Epub 2009 Aug 15.



Cohesin SMC1b protects telomeres in meiocytes
Adelfalk C, Janschek J, Revenkova E, Blei C, Liebe B, Göb E, Alsheimer M, Benavente R, De Boer E, Novak I, Höög C, Scherthan H, Jessberger R.
J Cell Biol. 2009 Oct 19;187(2):185-99.

Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase
Wojtasz L, Daniel K, Roig I, Bolcun-Filas E, Xu H, Boonsanay V, Eckmann CR, Cooke HJ, Jasin M, Keeney S, McKay MJ, Toth A
PLoS Genet. 2009 Oct;5(10):e1000702. Epub 2009 Oct 23